PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT MANGGIS (GARCINIA MANGOSTANA L) TERHADAP PERUBAHAN KADAR ENZIM ALT, AST HATI MENCIT JANTAN (MUS MUSCULUS L) STRAIN DDW SETELAH DIBERI MONOSODIUM GLUTAMATE (MSG) DIBANDINGKAN DENGAN VITAMIN E

Monosodium glutamate (MSG) is used as a food flavor enhancer has many side effects including, damage to liver function. This study examines the effect of ethanol extract of mangosteen peel (EEKM) compared with vitamin E on liver tampered with MSG, using true experimental designs. By using a sample of 20 male mice were divided into 4 treatment groups. Group (P0): control / distilled water 0.3 ml / mice / day (35 days), (P1): MSG 8mg/grBB mice / day (21 days), (P2): MSG 8mg/grBB mice / day (21 days ) followed EEKM 600mg/grBB/mice/hari (14 days), (P3): MSG 8 mg / grBB mice / day (21 days) followed vitamin E 0.2 mg / grBB mice / day (14 days), no significant differences serum levels of AST in P1 than P2, P3 (p <0.05), there was no significant difference between P2 compared to P3 (p> 0.05), for serum ALT levels, no significant differences in P1 compared to P2 (p <0, 05), but no significant difference between P2 compared to P3 (p> 0.05), there was no significant difference between P2 compared to P3 (p> 0, 05). Concluded that vitamin E may be able to reduce levels of serum AST, compared EEKM, whereas serum levels of ALT, EEKM not much different in lowering serum ALT levels compared with vitamin E