The Effect of Plectranthus amboinicus Lour Spreng Ethanolic Extract on Relative Organ, Body Weights Changes, and Hematology Profile in Wistar Rats Treated with 7,12Dimethylbenz(a)anthracene

The objectives of the current study were to investigate the effect of ethanolic extract of Plectranthus amboinicus L. Spreng (EEP) as a preventive and curative to the toxic effects of Rh-BB. Adult male rats were divided into eight groups: the negative control (CMC), the positive control (980 mg Rhodamin B)/kg bw, preventive 350, 700 and 1050 mg EEP / kg bw and curative 350, 700 and 1050 mg EEP / kg bw. EEP and Rhodamin-B was given by oral gavages. On preventive treatment was done by giving EEP from the 1st day to 42nd then rhodamin B was given from 21st to 42nd day. Whereas in curative treatment was done first by inducting rhodamin B from the first day to the 21st, then EEP is gave from the 22nd day until the 42nd. Parameters were observed namely body weight, organ ratio, ALT and AST. The data were analyzed with ANOVA and followed by LSD. The results showed that in preventive and curative treatment EEP dose 700 mg/kg bw increased body weight, 1050 mg/kg bw increased ratio liver weight to body weight significantly (p<0.05). On preventive treatment EEP decreased ALT and AST significantly, whereas in the curative treatment, not only ALT but also AST increased significantly in the treatment of Rhodamine-B and all EEP doses have to reduce the levels of ALT and AST.