Haematological Profile Of Rats (Rattus norvegicus) Induced BCG and Provided Leaf Extract of Plectranthus amboinicus Lour Spreng)

Silitonga, Melva and Silitonga, Pasar Maulim (2017) Haematological Profile Of Rats (Rattus norvegicus) Induced BCG and Provided Leaf Extract of Plectranthus amboinicus Lour Spreng). AIP Conference Proceedings, 1868 (1). 090008-1-090008-7. ISSN 0094-243X; 1551-7616

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Abstract

Plectranthus amboinicus Lour Spreng is a medicinal plant that has many benefits, such as an antioxidant,
hepatoprotective and immunostimulan. Immune status can be seen from hematological profile. This study aims to
investigate hematology profile on rats induced BCG and leaf extract of Plectranthus amboinicus. 24 male rats aged 3
months and weighing between 140-200 grams divided equally into six groups, P0, P1, P2, P3, P4 and P5. P0 as controle
was given aquadest. The P1, P2, P3, P4 and P5 treatment groups were given 19 g / kg AEP + BCG, 31.5 g / kg AEP +
BCG, 19g / kg AEP, 31.5 g / kg AEP and BCG consecutively. The BCG were used as antigen. The AEP was
administered orally for 30 days and 100 μl BCG were intramusculary administered on day 14 th and day 21. On day 31st,
the rats we decapitated and their blood were collected for hematology (leucocyte (WBC), Erythrocyte (RBC),
thrombocyte (PLT) count, Haemoglobin (Hb), erythrocyte sedimentation rate (ESR), MCV, MHC, and MHCH analysis.
Data were analyzed with ANOVA. WBC increased significantly in treatment AEP 31.5 g / kg bw, 31.5 g AEP / kg bw +
BCG and so were only given BCG. RBC tend to increase in all AEP treatment but tends to increase again when given a
BCG. Hb increased in treatment P1, P2, T3 and P4, but the improvement was significant only in treatment P1. While PLT
increase significantly in all treatments compared to the controls. HCT did not show significant differences but all of them
were in the normal range. EAP without BCG and with the addition of BCG lowered ESR significantly, whereas BCG
alone increased the ESR significantly. MCV increased significantly only in the treatment of P1 and show the same
pattern with the MHC and MHCH. The conclusion that Plectranthus amboinicus Lour a positive impact on blood profiles
with and without BCG. Plectranthus amboinicus Lour managed blood profile when administered together with BCG

Item Type: Article
Keywords: Haematological Profile Of Rats; BCG;
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
S Agriculture > SB Plant culture > SB599 Pests and diseases > SB950 Pest control and treatment of diseases. Plant protection > SB974 Organic plant protection. Biological control
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam
Depositing User: Mrs Catur Dedek Khadijah
Date Deposited: 08 Jun 2023 07:32
Last Modified: 08 Jun 2023 07:32
URI: https://digilib.unimed.ac.id/id/eprint/52517

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