Silitonga, Melva and Silitonga, Pasar Maulim and Sinaga, Erlintan (2023) Effect of aqueous infusion of Plectranthus amboinicus (LOUR) Spreng leaves on humoral immune system in rats. Tropical Journal of Pharmaceutical Research, 22 (05). pp. 1017-1022. ISSN 1596-5996 (p) ; 1596-9827 (e)
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Abstract
Purpose: To examine the effect of an aqueous infusion of Plectranthus amboinicus (AIP) on the immunological development of rats in response to Bacille Calmette-Guerin (BCG) antigen induction.
Methods: Twenty-four male rats, aged 3 months, were separated into six groups. Group 1 was normal control group without treatment, whereas groups 2 and 3 were the treatment groups induced with 100 μL BCG on days 7 and 14, followed by oral administration of AIP at doses of 19 and 31.5 g/kg, respectively. Groups 4 and 5 were treated only with AIP at doses of 19 and 31.5 g/kg respectively. Group 6 was a negative control group induced with 100 μL BCG on days 7 and 14. On day 31, IgG activity, antibody titer, lysozyme activity, relative organ weight, and lung histology were determined.
Results: The results showed that IgG levels, antibody titers, and lysozyme activity were significantly elevated in groups 4, 5, and 6 compared to normal control group (p < 0.05). Aqueous infusion of Plectranthus amboinicus and BCG had no effect on the relative weight of spleen. However, the therapy administered to rats in group 3 significantly increased their liver and lung mass (p < 0.05).
Conclusion: Aqueous infusion of Plectranthus amboinicus leaves stimulates the immune system in BCG-induced rats.
Item Type: | Article |
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Keywords: | Plectranthus amboinicus; Bacille Calmette-Guerin; Lysozyme; Humoral immune system |
Subjects: | Q Science > QD Chemistry > QD241 Organic chemistry Q Science > QD Chemistry > QD450 Physical and theoretical chemistry Q Science > QD Chemistry > QD71 Analytical chemistry |
Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam > Pendidikan Biologi |
Depositing User: | Mrs Harly Christy Siagian |
Date Deposited: | 05 Jun 2023 05:57 |
Last Modified: | 05 Jun 2023 05:57 |
URI: | https://digilib.unimed.ac.id/id/eprint/52401 |