Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac

Dalimunthe, Gabena Indrayani and Syahputra, Ricky Andi (2021) Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac. Journal Syifa Sciences and Clinical Research, 3 (2). pp. 78-86. ISSN E-ISSN: 2656-9612 P-ISSN:2656-8187

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Abstract

Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.

Item Type: Article
Keywords: Transfersomes; Diclofenac Sodium; Edge Activator; Transdermal
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD450 Physical and theoretical chemistry
Q Science > QD Chemistry > QD71 Analytical chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Mrs Catur Dedek Khadijah
Date Deposited: 28 Apr 2023 03:51
Last Modified: 28 Apr 2023 03:51
URI: https://digilib.unimed.ac.id/id/eprint/51892

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