Harahap, Novita Sari and Amelia, Rina (2019) RED DRAGON FRUIT (Hylocereus Polyrhizus) EXTRACT DECREASED LACTIC ACID LEVELAND CREATINE KINASE ACTIVITY IN RATS RECEIVING HEAVY PHYSICAL EXERCISE. Open Access Macedonian Journal of Medical Sciences, 07 (14). pp. 2232-2235. ISSN 1857-9655
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Abstract
BACKGROUND: Heavy physical exercise causes relative hypoxia. In hypoxic condition, the cell’s energy comes from anaerobic metabolism that produces lactic acid. An increment of oxygen need leads to ischemia-reperfusion, triggers free radical formation and damages muscles. Creatine kinase (CK) is a marker of muscle tissue damage. Red dragon fruit (RDF) has potential as antioxidant to reduce free radical formation.
AIM: This study aims to determine RDF extract potential to reduce the lactic acid level and CK activity after heavy physical exercise.
METHODS: A total of 32 male rats (Rattus Norvegicus) were randomly divided into 4 groups: group NORDF, treated heavy physical exercise and distilled water; group RDF100, treated heavy physical exercise and at 100 mg/kg BW RDF extract; group RDF200, treated heavy physical exercise and at 200 mg/kg BW RDF extract and group RDF300, treated heavy physical exercise and at 300 mg/kg BW RDF extract. The rats swam for 20 minutes, 3 times a week for 3 weeks.
RESULTS: RDF300 group showed lower lactic acid level and CK activity as compared to that of NORDF (p = 0.00) and RDF100 (p = 0.00) groups, but RDF300 are not significantly different for lactic acid (p = 0.45) and for CK (p = 0.68).
CONCLUSION: Red dragon fruit extract has potential in lowering lactic acid level and CK activity in male rats receiving heavy physical exercise.
Item Type: | Article |
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Keywords: | Lactic acid; Creatine kinase; Red dragon fruit; Exercise |
Subjects: | G Geography. Anthropology. Recreation > GV Recreation Leisure > GV201 Physical education and training > GV435 Physical measurements. Physical tests, etc. R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RS Pharmacy and materia medica > RS153 Materia medica > RS160 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) |
Divisions: | Fakultas Ilmu Keolahragaan > Ilmu Keolahragaan |
Depositing User: | Mrs Harly Christy Siagian |
Date Deposited: | 23 Jun 2021 06:00 |
Last Modified: | 23 Jun 2021 06:00 |
URI: | https://digilib.unimed.ac.id/id/eprint/42649 |