Antibacterial activity of various medicinal plants in North Sumatra against common human pathogens

becoming urgent, given the increasing number of
bacteria that are resistant to one or several antibiotics.
This study was aimed to assess the potential of 24 North
Sumatra, Indonesia medicinal plants as a source of
antibacterial compounds. Maceration with acetone
solvents was used to extract the content from the
medicinal plant samples. Then, antibacterial activity
tests were conducted via in vitro on 6 pathogenic
bacteria. The antibacterial screening was carried out
using the M02-A11 Clinical and Laboratory Standard
Institute (ClSI) diffusion method followed by the
determination of Minimum Inhibitory Concentration
(MIC) with Microdilution Methods M07-A9 (CSSI) and
determination of Minimum Bactericide Concentration
(MBC). Phytochemical tests were carried out on
extracts which showed high activity.
The results confirmed that most of the samples showed
antibacterial activity against 4 to 5 of test bacteria.
Strong antimicrobial activity was shown by Phyllantus
urinaria L extract against S. saprophyticus and Cassia
angustifolia plant extracts against B. cereus and S.
saprophyticus bacteria, each with a concentration of
312.5 ug/mL. The C. angustifolia is bacteriostatic,
whereas P. urinaria L is bactericidal with an MBC
value of 1250 ug/mL. Furthermore, P.urinaria contains
alkaloids, flavanoids, terpenoids, saponins and tannins
and so does C. Angustifolia.