THE EFFECT OF MANGOSTEEN (Garcinia mangostana L.) PEEL TO CREATINE KINASE SERUM IN MALE RATS (RATTUS NORVEGICUS) WITH FATIGUE FROM SWIMMING

Oxidative stress that occurs due to heavy physical exercise causes cells damage in the body, including muscle cells. Acute or chronic muscle cells damage can be marked by measuring the content of creatine kinase in the serum. Natural antioxidant consumption is a way to overcome the effect of oxidative stress. One of natural antioxidants is mangosteen (Garcinia mangostana L) peel with high content of antioxidants, xanthone and anthocyanin. The aim of this study is to understand the effect of mangosteen peels to creatine kinase serum in male rats (Rattus norvegicus) which have swimming fatigue. This is a true experimental study with post-test only control group design with 29 white rats as the experimental animals which were divided into 4 groups. The first group was given distilled water while the others groups were given mangosteen peels extract with dosage of 50, 100 and 200 mg/KgBW for 3 weeks. Physical activity, swimming, was done thrice in a week to all groups. Creatine kinase test was done at the last day of treatment where the rats had swum to fatigue. The average of creatine kinase serum shows a significant reduction. From the three dosage, 200 mg/KgBW of extract mangosteen peels is better to reduce creatine kinase serum content compared to the other two dosage in male rats. From this study, it can be concluded that mangosteen (Garcinia mangostana L) peels extract acts as antioxidant to lower creatine kinase serum in male rats (Rattus norvegicus) with swimming fatigue.