ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF NONPOLAR TO POLAR SOLVENT EXTRACTS OF Sarang Banua (Clerodenrum fragrans Vent Wild) LEAVES

Simorangkir, Murniaty and Hutabarat, Wesly and Nainggolan, Bajoka and Silaban, Saronom (2019) ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF NONPOLAR TO POLAR SOLVENT EXTRACTS OF Sarang Banua (Clerodenrum fragrans Vent Wild) LEAVES. RASĀYAN Journal of Chemistry [RJC], 12 (02). pp. 959-965. ISSN 0976-0083

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Abstract

Sarangbanua plant, known as Clerodendrumfragrans Vent Willd, is a division of the Verbanaceae family found in
Simalungun district of Indonesia, which is traditionally used as medicinal plants. The antioxidant and antibacterial activities of the C. fragrans leave extract was prepared by dissolving it in non-polar to polar solvents and treated by DPPH (1,1- diphenyl-2-picrylhydrazin) and diffusion methods. The results showed that the ethanol (polar) extract of the C. fragrans leaves had the highest antioxidant activity than ethyl acetate (semi-polar) and n-hexane (non-polar) extracts, which had IC50 values of 22.37 ppm, 27.26 ppm, and 88.77 ppm respectively. Vitamin C as a positive controlled with the IC50 value of 20.18 ppm. Furthermore, the ethyl acetate (semi-polar) extract of the C. fragrans leaves had the greatest inhibition value on Gram-positive bacteria of S. aureus (90.0%)with inhibitory zones of 11.25 ± 0.2 mm, meanwhile the n-hexane (non-polar) extract had the greatest inhibition against Gram-negative
bacteria of the E.coli(77.21%)with inhibitory zones of 10.5±0.3 mm.

Item Type: Article
Keywords: Clerodendrum fragrant Vent Willd; Antibacterial; Antioxidant; Polarity of solvent; Medicinal plant of Indonesian
Subjects: Q Science > QD Chemistry > QD450 Physical and theoretical chemistry
Q Science > QD Chemistry > QD71 Analytical chemistry
R Medicine > RS Pharmacy and materia medica > RS153 Materia medica > RS160 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Mrs Harly Christy Siagian
Date Deposited: 17 Apr 2020 07:24
Last Modified: 17 Apr 2020 07:44
URI: https://digilib.unimed.ac.id/id/eprint/39117

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