Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental

Situmorang, Putri Cahaya and Ilyas, Syafruddin and Siahaan, Doni Aldo Samuel and Restuati, Martina and Sari, Endang Ratna and Chairunisa and Maliki, Muhammad Faldhy (2022) Effect of Rhodomyrtus tomentosa Hassk. on HIF1α and VEGF expressions on hypertension placental. Journal of Pharmacy & Pharmacognosy Research, 10 (6). pp. 1076-1086. ISSN 0719-4250

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Context: HIF1α and VEGF are proteins marker oxidative stress and a decrease in placental growth factor (PlGF). Decreasing of HIF1α and VEGF in rats displayed
poor trophoblast differentiation, placental abnormalities, and fetal mortality. Rhodomyrtus tomentosa is a flowering plant in the Myrtaceae family that has the
potential to be a source of health-promoting chemicals.
Aims: To analyze HIF1α and VEGF in serum and hypertension placental tissue after giving Rhodomyrtus tomentosa (RHO) leaves extract.
Methods: Six treatments were given to the rats that were identified as being pregnant and pregnant rats with hypertension were given RHO with three doses:
(a) normal pregnant rats (control); (b) hypertensive rats; (c) hypertensive rats + 100 mg/kg BW of RHO; (d) hypertensive rats +200 mg/kg BW of RHO; and (e)
hypertensive rats + 400 mg/kg BW of RHO and (f) hypertensive rats + nifedipine. Under ketamine anesthesia, pregnant rats were removed on their 20th day of
gestation. Immunohistochemistry and ELISA were used to assess HIF1α and VEGF protein expression.
Results: There was a significant difference (p<0.01) in the expression of HIF1α and VEGF in the labyrinthine zone and yolk sac of the rat placenta between the
normal (C-) and hypertensive (C+) groups. HIF1α and VEGF expression decreased when RHO was administered at doses ranging from 100 to 400 mg/kg BW.
However, there was no significant change (p>0.05) in VEGF expression in the basal zone of the rat placenta across all groups.
Conclusions: Rhodomyrtus tomentosa leaves extract decreases HIF1α and VEGF expressions in serum and repairs the tissue of the placenta's labyrinth, basal,
and yolk sacs

Item Type: Article
Keywords: basal zone; HIF1α; hypertension; labyrinth zone; plant extract; VEGF; yolk sac
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH301 Biology > QH359 Evolution
Q Science > QH Natural history > QH301 Biology > QH540 Ecology
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam
Depositing User: Mrs Catur Dedek Khadijah
Date Deposited: 05 Apr 2023 08:21
Last Modified: 05 Apr 2023 09:26
URI: https://digilib.unimed.ac.id/id/eprint/51640

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