EFEK EKSTRAK DAUN RANTI HITAM (SOLANUM BLUME NEES EX BLUME) TEWRHADAP KADAR LDL DAN HDL SERUM DARAH TIKUS (RATTUS NORVEGICUS) YANG DIBERI PAKAN LEMAK TINGGI

Gultom, Jelita (2017) EFEK EKSTRAK DAUN RANTI HITAM (SOLANUM BLUME NEES EX BLUME) TEWRHADAP KADAR LDL DAN HDL SERUM DARAH TIKUS (RATTUS NORVEGICUS) YANG DIBERI PAKAN LEMAK TINGGI. Undergraduate thesis, UNIMED.

[img] Text
1. NIM.4133210015 COVER.pdf - Published Version

Download (0B)
[img] Text
2. NIM. 4133210015 LEMBAR PENGESAHAN.pdf - Published Version

Download (0B)
[img] Text
3. NIM. 4133210015 ABSTRAK.pdf - Published Version

Download (0B)
[img] Text
4. NIM. 4133210015 KATA PENGANTAR.pdf - Published Version

Download (0B)
[img] Text
5. NIM. 4133210015 DAFTAR ISI.pdf - Published Version

Download (0B)
[img] Text
6. NIM. 4133210015 DAFTAR GAMBAR.pdf - Published Version

Download (0B)
[img] Text
7. NIM. 4133210015 DAFTAR TABEL.pdf - Published Version

Download (0B)
[img] Text
8. NIM. 4133210015 DAFTAR LAMPIRAN.pdf - Published Version

Download (0B)
[img] Text
9. NIM. 4133210015 BAB I.pdf - Published Version

Download (0B)
[img] Text
13. NIM. 4133210015 BAB V.pdf - Published Version

Download (0B)
[img] Text
14. NIM. 4133210015 DAFTAR PUSTAKA.pdf - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Generate index codes conversion from text to indexcodes)
indexcodes.txt - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg - Published Version

Download (0B)
[img] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg - Published Version

Download (0B)

Abstract

Aterosklerosis merupakan penyakit yang disebabkan karena terbentuknya plak di dinding arteri dan dapat berkembang menjadi pembunuh utama di Indonesia. Faktor resiko aterosklerosis antara lain karena tingginya kadar LDL dan rendahnya kadar HDL. Salah satu alternatif alami untuk menurunkan LDL dan menaikkan HDL adalah dengan adanya kandungan flavonoid yang dapat menghambat HMG-CoA Reduktase sehingga menyebabkan penurunan sintesis kolesterol sehingga LDL menurun. Salah satu tanaman yang mengandung flavonoid adalah ekstrak daun ranti hitam. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun ranti hitam (Solanum blumei Nees ex Blume) terhadap kadar HDL dan LDL serum tikus putih (Rattus norvegicus) yang diberi pakan lemak tinggi. Penelitian ini menggunakan RAL, dengan empat perlakuan yaitu K2 (Kontrol positif yaitu dengan simvastatin 0,25 mg/200 g BB), K3 (ekstrak n-heksan 250 mg/kg BB), K4 (ekstrak etilasetat 250 mg/kg BB), dan K5 (ekstrak etanol 250 mg/kg BB). Sebelum dilakukan perlakuan pakan lemak tinggi (K2 –K5) terlebih dahulu diukur kadar HDL dan LDL untuk pengaruh pakan lemak tinggi yaitu pada Kelompok K0 (kontrol negatif yaitu tanpa perlakuan) dan K1 (kontrol lemak yaitu dengan pakan lemak tinggi). Data kemudian dianalisis dengan ANAVA. Hasil penelitian menunjukkan bahwa ekstrak daun ranti hitam berpengaruh terhadap kadar HDL dan LDL serum darah tikus putih (Rattus norvegicus) yang diberi pakan lemak tinggi. Ekstrak yang paling efektif dalam menaikkan kadar HDL dan menurunkan kadar LDL adalah ekstrak etanol. Hal ini terjadi karena adanya kandungan metabolit sekunder pada ekstrak etanol daun ranti hitam seperti flavonoid, fenol saponin dan tanin.

Item Type: Thesis (Undergraduate)
Contributors:
ContributionNameNIDN/NIDK
Thesis advisorSimorangkir, Murniaty195905041984032001
Call Number: SK-2017 KIM 034
Keywords: Solanum blumei Nees ex Blume; HDL; LDL
Subjects: Q Science > QD Chemistry
Q Science > QL Zoology > QL605 Chordates. Vertebrates > QL640 Reptiles and amphibians
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Mrs Siti Nurbaidah
Date Deposited: 10 Aug 2017 09:54
URI: http://digilib.unimed.ac.id/id/eprint/25549

Actions (login required)

View Item View Item