PENGARUH PEMBERIAN EKSTRAK KULIT BATANG KAYU RARU (VATICA PAUCIFLORA BLUME) SEBAGAI ANTIDIABETES TERHADAP TIKUS WISTAR YANG DIINDUKSI ALOKSAN

Manurung, Debora Tantia (2012) PENGARUH PEMBERIAN EKSTRAK KULIT BATANG KAYU RARU (VATICA PAUCIFLORA BLUME) SEBAGAI ANTIDIABETES TERHADAP TIKUS WISTAR YANG DIINDUKSI ALOKSAN. Undergraduate thesis, UNIMED.

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Abstract

Penelitian ini menggunakan sampel kulit batang kayu raru yang berasal dari Tapanuli Tengah yaitu jenis Vatica Pauciflora Blume. Proses pengambilan ekstrak dilakukan dengan cara perebusan terhadap sampel sesuai dengan cara komsumsi masyarakat. Penelitian ini bertujuan untuk melihat pengaruh pemberian terhadap tikus yang mengalami diabetes untuk dapat digunakan sebagai antidiabetes. Telah dilakukan penelitian analisa fitokimia diperoleh hasil bahwa didalam ekstrak kulit batang kayu raru (Vatica Pauciflora Blume) mengandung senyawa flavonoid, tannin, saponin dan kuinon yang dapat menurunkan kadar glukosa darah yang disebabkan oleh defesiensi sel β pankreas dalam produksi insulin. Penggunaan aloksan yaitu sebagai penyebab radikal bebas yang diakibatkan oleh terganggunya permeabelitas sel β pankreas. Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) One Way, dengan faktor yaitu konsentrasi ekstrak kulit batang kayu raru (Vatica Pauciflora Blume) terdiri dari 5 konsentrasi yang berbeda yaitu: K0 (0 mg/kg BB), K1 (0 mg/kg BB), K2 (65 mg/kg BB), K3 (130 mg/kg BB) dan K4 (195 mg/kg BB). Kadar glukosa darah diukur dengan glukometer easy touch GCU. Analisis data diperoleh bahwa konsentrasi ekstrak kulit batang kayu raru (Vatica Pauciflora Blume) dalam menurunkan glukosa darah sebanding dengan kenaikan konsentrasi dan dosis optimum adalah pada konsentrasi 195 mg/kg BB dengan keefektifan mencapai 89,8 mg/dL. Berdasarkan hipotesis untuk pemberian ekstrak diperoleh nilai F hitung 18,6047 > F tabel 2,866. H0 ditolak yang berarti ada pengaruh. Uji selanjutnya dengan uji DMRT 5% kelompok perlakuan ekstrak terlihat berbeda nyata dalam menurunkan glukosa darah bila dibandingkan dengan kelompok kontrol normal dan tidak berbeda nyata dibandingkan dengan kelompok aloksan.

Item Type: Thesis (Undergraduate)
Contributors:
ContributionNameNIDN/NIDK
Thesis advisorRiris, Ida Duma195802291980112001
Call Number: 540 Man p
Keywords: Ekstrak Kulit Batnag Kayu Raru; Antidiabetes; Tikus Wistar; Aloksan
Subjects: L Education > LB Theory and practice of education > LB1025 Teaching (Principles and Practice)
Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Pendidikan Kimia
Depositing User: Mrs Elita Sari Sitorus
Date Deposited: 08 Apr 2016 08:34
URI: http://digilib.unimed.ac.id/id/eprint/10107

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