ANTICHOLESTEROL ACTIVITY OF ETHANOL EXTRACT OF RANTI HITAM (Solanum blumei Nees ex Blume) LEAVES: IN VIVO AND IN SILICO STUDY

Ranti Hitam known as local name of (Solanum blumei Nees ex Blume) found in the Dairi, Sumatera Utara, Indonesia. It is used by the community as traditional medicine which contains of various phytochemical constituent of steroidal alkaloids of β2-solanin, diosgenin, flavonoids, saponins and tannins. The purpose of the study was to investigate the anticholesterol activity of the ethanol extract of (Solanum blumei Nees ex Blume) by in vivo and insilico methods. A number of 15 rats were divided into 5 treatment groups as in vivo high fat diet model, otherwise insilico study was carried out to determine the activity of main compound of S. blumei in inhibiting HMG Co-A reductase. The bioactive compounds of S. blumei, diosgenin (C26H39O4) and β2-solanine (C39H63NO11) showed inhibition activity to HMG-CoA reductase by in silico and invivo test and it was indicated that 2 bioactive compounds of S. blumei had anticholesterol activity.