INVESTIGATION OF ANTIBACTERIAL ACTIVITY AND CELL VIABILITY OF Ag/Mg AND Ag/Zn Co-DOPED HYDROXYAPATITE DERIVED FROM NATURAL LIMESTONE

Sinulingga, Karya and Sirait, Makmur and Siregar, Nurdin and Doloksaribu, Maryati Evivani (2021) INVESTIGATION OF ANTIBACTERIAL ACTIVITY AND CELL VIABILITY OF Ag/Mg AND Ag/Zn Co-DOPED HYDROXYAPATITE DERIVED FROM NATURAL LIMESTONE. ACS Omega, 06 (49). pp. 34185-34191. ISSN 2470-1343

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Official URL: https://pubs.acs.org/doi/10.1021/acsomega.1c05921

Abstract

Improving the antibacterial activity to avoid infections and keeping the biocompatibility at a safe level of HAp-based materials is highly important for biomedical applications. In this work, we investigate the antibacterial activity of 2.5Ag/2.5Mg co-doped HAp and 2.5Ag/2.5Zn co-doped HAp toward Escherichia coli bacteria. Moreover, their biocompatibility for osteoblastic cells (MC3T3-E1 cells) was also evaluated. The physical properties were characterized with necessary characterization tools such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Brunauer−Emmett−Teller. Both 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp consist of hydroxyapatite (HAp) and beta calcium triphosphate (β-TCP) phases. The antibacterial test reveals that 2.5Ag/2.5Mg co-doped HAp or 2.5Ag/2.5Zn co-doped HAp has an outstanding antibacterial activity with a killing rate of 99 ± 1%. More importantly, the cell viability for osteoblast cells with 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp promotes the proliferation much more effectively than 2.5Ag-doped HAp or 5Ag-doped HAp.

Item Type: Article
Keywords: Antibacterial; Cell viability; Hydroxyapatite; Natural limestone
Subjects: Q Science > QC Physics
Q Science > QC Physics > QC120 Descriptive and Experimental mechanics
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Pendidikan Fisika
Depositing User: Mrs Harly Christy Siagian
Date Deposited: 10 Mar 2022 08:09
URI: http://digilib.unimed.ac.id/id/eprint/45693

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