Effect of jamblang (syzygium cumini (l) skeels.) aceh ethanol extract to blood sugar levels in rats (rattus norvegicus)

This study aimed to analyze the effect of ethanol extract jamblang (Syzygium cumini (L) Skeels) Aceh to (i) a levelof sugar in blood, and (ii) the level of body weight (BW) in rats with diabetes mellitus (DM). Type of this research was experimentally using non factorial completely randomized design. This research was using 20 male rats (Rattusnorvegicus) Wistar which divided into five groups: (i) negative control / non diabetes mellitus (NC), (ii) positive control (PC), (iii) control drug / group of non DM with treatment 200 mg / kg (TC), (iv) diabetic group with treatment 200 mg / kg (T2), and (v) diabetic group with treatment 300 mg / kg (T3). DM conditions obtained by alloxan induction with dose of 150 mg / kg were injected intraperitoneally. Sugar blood measurement was done using a glucometer, two days after alloxan induced. Rats with level of sugar blood ≥ 200 mg / ml otherwise have diabetes. Then, DM rats were given by ethanol extract of jamblangevery other day for 28 days orally using a needle probe. Jamblang ethanol extract was made by maceration method with solvent in the form of 96% ethanol. Measurement of blood sugar levels and body weight is done every four days, and measurements are taken in the morning. The results of measurements of blood sugar levels and body weight were analyzed by one-way ANOVA through Tukey’s test using SPSS 21.0 software. The results showed that the treatment of ethanol extract of jamblang with a dose of 200 mg / kg body weight had an effect on weight loss and increased blood sugar levels in rats with DM rats. But in non-DM rats treatment with a dose of 200 mg / kg body weight did not give effect on weight gain and blood sugar levels. In the treatment with a dose of 300 mg / kg body weight did not give effect to weight loss and increased blood sugar levels in rats with DM or non-DM. In general it can be concluded that the treatment of ethanol extract of jamblang can increase body weight and reduce blood sugar levels of DM patients.