THE EFFECT OF MANGOSTEEN RIND EXTRACT (Garcinia mangostana L) TOWARD STRESS OXIDATIVE, LEUKOCYTES TYPE COUNTS ON MALE RATS (Rattus norvegicus) WITH EXCESSIVE PHYSICAL ACTIVITY

Sinaga, Rika Nailuvar and Zulaini, (2020) THE EFFECT OF MANGOSTEEN RIND EXTRACT (Garcinia mangostana L) TOWARD STRESS OXIDATIVE, LEUKOCYTES TYPE COUNTS ON MALE RATS (Rattus norvegicus) WITH EXCESSIVE PHYSICAL ACTIVITY. Open Access Macedonian Journal of Medical Sciences, 08 (A). pp. 904-909. ISSN 1857-9655

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Official URL: https://doi.org/10.3889/oamjms.2020.5448

Abstract

BACKGROUND: Excessive and heavy physical activity could lead to the oxidative stress in the body. This condition can affect several blood parameters such as malondialdehyde (MDA), glutathione peroxidase (GPx), leukocytes, and its type counts. One way to overcome the effects of oxidative stress due to strenuous physical activity is by giving natural antioxidants. Mangosteen rind (Garcinia mangostana L.) contains considerable antioxidants, namely, xanthones and procyanidin.AIM: This research aimed to investigate the effect of mangosteen rind extract (MRE) on oxidative stress parameters, leukocyte count, and leukocyte count in male rats (Rattus norvegicus) that received excessive physical activity. METHODS: This study was purely experimental research with a post-test only control group design, using 29 white rats (R. norvegicus) as experimental animals, which were divided into four groups. The first group (P1) received distilled water and the other group received MRE at a dose of 50 mg/KgBW (Body Weight) (P2), 100 mg/KgBW (P3), and 200 mg/KgBW (P4) for 3 weeks, respectively. Swimming as a physical activity was carried out 3 times a week in all groups. Examination of leukocyte count and species was carried out on the last day of treatment after the rats swam to fatigue. RESULTS: MDA levels did not decrease significantly while GPx activity increased significantly. Moreover, the average leukocytes and lymphocytes showed a decrease but not significant. A significant decrease in the percentage of neutrophils and basophils was obtained by P4 group compared to others. In addition, a significant decrease in the average percentage of eosinophils for P3 and P4 groups was obtained. Furthermore, P3 and P4 group exhibit significant increase of the average percentage of monocytes. CONCLUSION: MRE as an antioxidant affects the levels of neutrophils, basophils, eosinophils, and monocytes but not in MDA, GPx, leukocytes, and lymphocytes.

Item Type: Article
Keywords: malondialdehyde; Glutathione peroxidase; Leukocytes; Excessive physical activity; Mangosteen rind extract
Subjects: G Geography. Anthropology. Recreation > GV Recreation Leisure > GV201 Physical education and training > GV435 Physical measurements. Physical tests, etc.
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RS Pharmacy and materia medica > RS153 Materia medica > RS160 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Divisions: Fakultas Ilmu Keolahragaan > Ilmu Keolahragaan
Depositing User: Mrs Harly Christy Siagian
Date Deposited: 18 Feb 2021 07:22
URI: http://digilib.unimed.ac.id/id/eprint/41294

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