THE SEPARATION OF RARU (VATICA PAUCIFLORA BLUME) BARK ETHANOL EXTRACTS WHICH HAS Α-GLUCOSIDASE INHIBITOR (IN VITRO) USING THE CHROMATOGRAPHY COLUMN

Riris, Ida Duma and Napitupulu, Martina Asiati (2016) THE SEPARATION OF RARU (VATICA PAUCIFLORA BLUME) BARK ETHANOL EXTRACTS WHICH HAS Α-GLUCOSIDASE INHIBITOR (IN VITRO) USING THE CHROMATOGRAPHY COLUMN. In: The 3rd Annual International Seminar on Trends in Science and Science Education 2016, 7 Oct 2016, Medan.

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Official URL: http://sitsefmipa.unimed.ac.id/proceeding2016/sits...

Abstract

The study aims to identify and characterize the alpha-Glucosidase inhibitory activity of the Raru (Vatica pauciflora Blume). The inbitory activity was found in aqueous ethanol extracts of bark of the stem. Column Chromatography was used and found for the process of fractination. The 1st coloum of the ethanol extract fractination showed IC50 of 94.94 as an inhibitors towards the enzyme -glucosidase. The compounds of the 1st column were separated again (2nd column) and showed the IC50 of 92.49. The 3rd chromatography column was conducted and produced one single compound on the fraction of 9-4-4-1 with the IC50 of 93.46. In every once separation of the Raru bark epidermis produced 40.2 mg single fraction. This compound will be used to explore the effect of the compound on the decreasing of the sugar level of alloxan- induced Wistar rats.

Item Type: Conference or Workshop Item (Paper)
Keywords: Chromatography; Traditional medicine; Blood sugar level
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD71 Analytical chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Mrs Yuni Chairani
Date Deposited: 13 Dec 2017 02:47
URI: http://digilib.unimed.ac.id/id/eprint/27745

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