SINTESIS SENYAWA KALKON (E)-1-(4-KLOROFENIL)-3-ISOPROPILFENIL)PROP-2-EN 1-ON DAN UJI TOKSISITASNYA

Halogen substituted analogoues compounds chalcone, (E)-1-(4-klorofenil)-3-(4-isopropilfenil) prop-2-en-1-on, was synthesized from 4-isopropilbenzaldehyde as aldehydes with 4-chloroacetophenone as ketones by using aldol condensation reaction. The compound resulted rendement with value of 64,90% and characterized by using UV, IR, MS, and 1HNMR. Toxicity tests using Brine Shrimp Lethality Test (BSLT) showed that those compounds have a potency as anticancer agent with LC50 value 3,98 μg/mL.